Protein Details: Calcium-activated chloride channel regulator 1
Protein ID
ICDB_Pro_1102
Protein Name
Calcium-activated chloride channel regulator 1
Gene Name
CLCA1
Organism
Macaca mulatta (Rhesus macaque)
Length
913 amino acids
AlphaFoldDB
AF-Q6PT52-F1-model_v4.pdb
Function
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity).
Sequence
MGPFKSSVFILILHLLEGALSDSLIQLNNNGYEGIVIAIDPNVPEDETLIQQIKDMVTQASPYLFEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPSGGDEPYTEHIGKCGDQGERIHLTPHFLAGKQLKEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSVGITGKIEVNKCQGGSCYTKRCTFNKATGLYEKGCEFIPHSQQTEKASIMFAQHVDSVVEFCTEQNHNKEAPNMQNTKCNLRSTWEVIRDSEDFKKTTPTTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQIIELRSWVGMVTFDSAAHVQSELIQINSGSDRDTLTKRLPTAASGGTSICSGLRLAFTVIKKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAARELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGVVSERSIQLESKGSTLQNSQWMNGTVIVDSTVGKDTLFLVTWTTQPPQILLWDPSGQKQDGFVVDKNTKMAFLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASSATLPPITVTSKMNKDTGKFPSPMIVYANIRQGASPILRASVTALIESENGKTVTLELLDNGAGADAAKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAVRRRAIPQQSGVMYIPGWIENDEIQWNPPRPEIEDDVQRKQVCFSRTSSGGSFVASGVPNAPIPDLFPPCQITDLKAEIHGHSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNISINSTIPGIHILKIMWKWIGELQLSIG
PDB Structures
Ligand Binding
Binding Site
BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";
Disease
Location
DOI ID
RefSeq
NP_001028084.1